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E-mail
service@aitesenctm.com
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Phone
18118481917
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Address
3106, Comprehensive Building 7, Fangzheng Zhigu, No. 155 Suhong East Road, Suzhou Industrial Park
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Suzhou Aitson Pharmaceutical Equipment Co., Ltd
Twin screw hot melt extruder
NegotiableUpdate on 05/26
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Overview
Double screw hot melt extruder ZE-16HME Double screw hot melt extrusion technology: 1. Plastic industry development, drug hot melt extrusion (HME) technology is becoming a new type of drug delivery technology. 2. Creative combination of processing technology and pharmacy for drug delivery. 3. Sample can be processed above the glass transition temperature of polymer materials···
Product Details
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Twin screw hot melt extruder
ZE - 16 |
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HMETwin screw hot melt extrusion technology:
l Plastic industry development, drug hot melt extrusion (HME) technology is becoming a new type of drug delivery technology
l Creatively combining processing technology with pharmacy for drug delivery
l Samples can be processed above the glass transition temperature of polymer materials
l Effective mixing of thermoplastic adhesives and/or polymers, active ingredients at the molecular level
l Combining the advantages of solid dispersion technology and mechanical manufacturing
l Less dust, continuous operation, good reproducibility, high production efficiency, and can be monitored online
l Can promote the dissolution of insoluble active ingredients, improve bioavailability, and can also be used to prepare sustained-release formulations
l Can be used to prepare flavor masking microspheres or other special shaped formulations, such as film formulations, stick formulations, and hollow cylindrical formulations
l Short extrusion duration, no need to add water or organic solvents, no need to heat and dry, and not easily hydrolyzed
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ZE - 16It is a model suitable for small-scale experiments and medium scale sample sizes, and the screw configuration is optional, suitable for processing samples of different types and requirements. Technical features: l Building block screw:By using a single screw with hollow building block thread elements of different pitches, multiple drugs can be processed, which changes the disadvantages of long production cycle and high cost of traditional screws. l Design features:The overall molding design of the barrel, with mirror polished screws, conforms toGMPSet requirements. l Multi stage temperature control:passMCHCeramic heater,PID PT100Sensor control,SIMENSE 200Smart，PLCComposed by combining and heating the final material. The material has reached a molten state and can ensure that the material does not lose its medicineAPIIntegrity. l Sealing system design:The system adopts a stainless steel surface fitting and sealing design, and there is no sealing ring inside the barrel to ensure the purity and sterility of the drug. l PLCcontrol systemadoptGEFRANDigital melt pressure gauge, combined with temperature control probe, realizes the automation of pressure and temperature display, recording, control and alarm functions of the entire system. |
Application type:
l Preparation of solid dispersion system — Hot melt granulation of insoluble drugs and solubilizing excipients to improve drug release and bioavailability;
l Taste masking technique–Melting and granulating drugs with poor taste and masking polymer materials together, and then crushing them to lay a good foundation for preparing oral liquids, dry mixtures, or orally disintegrating tablets;
l Preparation of slow-release particles–Melting and granulating drugs with polymer sustained-release materials can produce very uniform sustained-release particles in one step, and can also be used to make other sustained-release formulations.
Existing cases:
l accessoriesPEG
l accessoriesPEG
l LopinavirAuxiliary material copolymer ketone
l TraglitazoneAuxiliary material copolymer ketone
Technical Specifications:
l Motor power:1.5Kw
l Speed range:0~600rpm
l Screw diameter:15.6mm
l Can be matched with mouth mold: round rod installation, diameter2mm
l working pressure:0~100bar
l Barrel material: high nitrogen martensitic stainless steelWR30
l Weight:112Kg
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