Experimental ultrafiltration system LDS-L2

Experimental ultrafiltration system LDS-L2

Experimental Ultrafiltration System LDS-L2

Tangential Flow Filtration

Tangential Flow Filtration，TFF

Tangential Flow Filtration (TFF) is currently a widely used membrane separation method. The sample is driven by pressure, and the contents are separated by membrane filtration according to different molecular sizes, achieving the goals of removing pyrogen, displacing solution environment, purification, and concentration.

Tangential Flow Filtration (TFF) is a widely used membrane separation method. Driven by pressure, the contents of the sample can be separated by membrane filtration according to different molecular sizes, so as to remove pyrogen, replace solution environment, purify and concentrate.

The membrane components for tangential flow filtration are usually membrane packs or hollow fiber columns, both of which have multiple models to meet different usage needs. The type and pore size of the membrane material, solution circulation flow rate, pressure on both sides of the membrane, sample temperature, process time, and other parameters are very important for tangential flow filtration. They determine the final process effect, as well as the feasibility and specific plan for large-scale production. The tangential flow filtration equipment at the laboratory scale is dedicated to obtaining feasible process solutions and reliable process parameters, determining suitable process parameters for large-scale experiments and production, and providing effective basis for equipment or system selection.

The membrane components of tangential flow filtration are usually membrane package or hollow fiber column, both of which have a variety of models to meet different use needs. Membrane material type and pore size, solution circulation flow rate, pressure on both sides of the membrane, sample temperature, process time and other parameters are very important parameters for tangential flow filtration. They determine the final process effect, as well as the feasibility and specific scheme of large-scale production. The laboratory scale tangential flow filtration equipment is committed to obtaining feasible process schemes and reliable process parameters, determining appropriate process parameters for large-scale test and production, and providing an effective basis for equipment or system selection.

Liposomes encapsulating small molecule drugs and lipid nanoparticles encapsulating nucleic acid drugs are currently two very popular types of drug carriers, which require tangential flow filtration for sample processing in both research and production.

Liposomes coated with small molecule drugs and lipid nanoparticles coated with nucleic acid drugs are two very popular drug carriers. They need to use tangential flow filtration to treat samples in R & D and production.

Figure 1: Flow Chart of Ultrafiltration System

Figure 1: flow chart of ultrafiltration system

According to the retention pore size of the filter membrane, filtration can be classified into clarification filtration, microfiltration, ultrafiltration, nanofiltration, and reverse osmosis. Filtering membranes with different pore sizes using tangential flow operation can be referred to as tangential flow microfiltration and tangential flow nanofiltration.

The filtration can be divided into clarification filtration, microfiltration, ultrafiltration, nanofiltration and reverse osmosis. Tangential flow microfiltration and tangential flow nanofiltration can be referred to as tangential flow microfiltration and tangential flow nanofiltration.

Figure 2: Classification of filter membrane pore size

Figure 2: filter membrane pore size classification

The functions of the Aitson LDS series ultrafiltration system

Functions of AITESEN LDS Series Ultrafiltration System

This system is mainly applied in the fields of sample concentration, purification, dialysis, replacement buffer, and solution heat removal. During the process, the weight of the sample, pre membrane pressure, reflux pressure, permeation pressure, transmembrane pressure TMP, and other data can be displayed and recorded through a paperless recorder or LCD panel.

The system is mainly used in the demａnd fields of sample concentration, purification, dialysis, replacement buffer and solution pyrogen removal. In the process, the weight, pre membrane pressure, reflux pressure, permeation pressure, transmembrane pressure TMP and other data of the sample can be displayed and recorded through paperless recorder or liquid crystal panel.

The application areas include:

Applications include:

Ÿ Purification of chemical drug liposomes, such as hydrochloric acid liposomes, irinotecan liposomes, etc;

Purification of chemical drug Liposomes, such as doxorubicin hydrochloride liposomes and irinotecan liposomes;

Ÿ Purification of nucleic acid drugs and vaccines, such as lipid nanoparticles, polymer nanoparticles, mRNA LNP, siRNA LNP, etc;

Purification of nucleic acid drugs and vaccines, such as lipid nanoparticles, polymer nanoparticles, mRNA LNP, siRNA LNP, etc;

Ÿ Separation and purification of biological cell products, which can collect cells from fermentation broth and remove cell debris, etc;

Separation and purification of biological cell products, which can collect cells from fermentation broth and remove cell fragments;

Ÿ Purification of vaccines, monoclonal antibodies, and recombinant protein drugs;

Purification of vaccines, monoclonal antibodies and recombinant protein drugs;

Ÿ Displacement buffer solution;

Displacement buffer solution;

Ÿ Other applications for separation and purification based on the principle of molecular size.

Other uses of separation and purification based on molecular size principle.

Technical Specifications

Technical Parameter

Aitson can customize design and integration according to user needs, and its technical parameters will be provided separately. Customizable types include:

AITESEN can carry out customized design and integration according to user needs, and its technical parameters are provided separately. Customizable types include:

Ÿ Different sample volumes;

Different sample volumes;

Ÿ Requirements for different control methods;

Requirements of different control modes;

Ÿ Requirements for different levels of configuration;

Requirements of different preparation grades;

Ÿ General/specific type requirements;

General / special requirements;