Beebio Hollow Fiber Ultrafiltration System

Hollow fiber ultrafiltration system

Filtration is the most commonly used separation and purification technology in the biopharmaceutical industry. According to the different injection methods of the filter, it can be divided into direct flow filtration (DFF) and tangential flow filtration (TFF). In the traditional DC filtration method, the sample liquid is vertically "pressed" over the surface of the filter membrane, which can easily cause filter blockage or contamination, hence it is also known as dead end filtration; In the tangential flow through the filter, the injection liquid circulates parallel to the membrane surface in a "tangential" direction, which can form a "sweeping" effect on the accumulated materials on the membrane surface, reducing the risk of membrane pore blockage or membrane fouling and increasing the continuous processing capacity of the filter.

Schematic diagram of tangential flow filtration

Industry Applications

• Cell perfusion culture
• Cell harvesting
• Cell or lysate clarification
• Purification and concentration of target products such as recombinant proteins and viruses
• Purpose: Wash and filter the product/change the solution
• Rinsing of drug carriers such as liposomes and nanoparticles

Product Features

• Can handle up to 50% solid content liquid materials
• Strong anti pollution ability
• Widespread drug resistance
• Stable high-throughput

Application Cases

Membrane column selection

System Selection