Suitable for SPE column purification process, 12 bit, 24 bit and can be combined with multiple independent flow paths to prevent cross contamination. Anti fogging vacuum chamber design, easy to operate, fast and flexible to use, capable of processing individual sample liquids and batch processing samples. The vacuum chamber is made of thickened glass and can withstand negative values above -80Kpa. The new material tube frame is corrosion-resistant and can adjust brightness arbitrarily. It is suitable for independent valves at the inlet of various specifications of test tubes, durable and easy to operate