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2954198810@qq.com
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Phone
13651667376
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Room 3661, No. 13, Lane 65, Huandong 1st Road, Fengjing Town, Jinshan District, Shanghai
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Shanghai Huifen Scientific Analysis Instrument Co., Ltd
Detection of residual solvents in drugs by gas chromatography
NegotiableUpdate on 01/21
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Overview
Brief description: The detection and control of residual solvents in drugs are key steps in drug production; Due to the presence of adhesives in tablets, solid tablets cannot be directly analyzed by gas chromatography. The use of gas chromatography and headspace sampler to detect residual solvents in drugs is one of the detection methods.
Product Details
| brand | Shanghai Huifen |
|---|
Detection of residual solvents in drugs using gas chromatography, equipped with an automatic headspace sampler for injection, capillary column separation, and hydrogen flame detector for residual solvent content detection. The solution developed by our company is easy to operate, short in time, effective, and efficient. It is a testing solution for quality control in pharmaceutical factories and food and drug testing centers.
Gas chromatograph analysis process for residual solvent detection in drugs:
Sample preparation - Automatic headspace sampler quantitative tube injection - Gas chromatograph analysis - Chromatography workstation - Data output
Analysis conditions:
Chromatography column: 30m * 0.53mm * 1um SE-30
Temperature: Column temperature 60℃ Constant Temperature Detector FID: 250 ℃
Headspace conditions: equilibrium temperature (pipeline, injection port) 800 ℃, equilibrium pressure 34.5Kpa, injection time 0.15min
定量管： 1ml 分隔管路温度90℃, separation equilibrium time: 30 minutes
Carrier gas: Nitrogen
Instrument technical specifications:
1. Temperature control:
(1) Column temperature:
·Temperature control range: room temperature plus 8 ℃ to 420 ℃ (set temperature increment of 1 ℃)
Temperature control accuracy: ± 0.1 ℃ within 200 ℃
± 0.2 ℃ above 200 ℃
Temperature gradient: not greater than 1% within the effective area of the column
The deviation between the indicated temperature and the set temperature shall not exceed 0.5 ℃
The deviation between the actual temperature and the indicated temperature shall not exceed 2%
Cheng Sheng order: Linear 8th order.
Automatic rear door cooling function.
Heating rate: 1-30 ℃/min, with increments of 1 ℃/min
Initial time, final time: 0-255 minutes, with increments of 1 minute
The repeatability of program heating should not exceed 2%
The maximum heating power is 1500W
The temperature sensing element adopts PT100 corundum ceramic platinum resistor
(2) Vaporization chamber temperature:
Temperature control accuracy: ± 0.1 ℃ within 200 ℃
± 0.2 ℃ above 200 ℃
The maximum operating temperature is 420 ℃.
Adopting vertical heating and two 100W internal heating stainless steel heating rods
The temperature sensing element adopts PT100 corundum ceramic platinum resistor
(3) Temperature of hydrogen flame detection room:
Temperature control accuracy: ± 0.1 ℃ within 200 ℃
± 0.2 ℃ above 200 ℃
The maximum operating temperature is 420 ℃.
Adopting horizontal heating and two 90W internal heating stainless steel heating rods
The temperature sensing element adopts PT100 corundum ceramic platinum resistor
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