In the pharmaceutical industry, the size and shape of sample particles are crucial. The particle morphology can affect the delivery performance of inhalable drugs, the dissolution characteristics of tablets, formulation quality, solubility or absorption, and many other aspects. Like many industries, the requirement for particle size is evolving towards smaller and finer sizes. In order to meet the requirements of analysis and ensure that the final sample is representative, we hope to grind very small samples. The particle size range typically required by laboratory analysts is from 10 μ m to 2mm.

In addition, there are many applications that require smaller sizes, such as detecting active ingredients, which requires grinding the sample to the sub micron range, and then extracting the sample DNA or RNA for cell lysis.
The material composition and physical properties of the samples vary greatly. In order to ensure that the materials are not contaminated or remain unchanged, different grinding principles and auxiliary conditions need to be used to complete the pre-treatment. A common example is low-temperature freezing grinding, which requires the use of dry ice or liquid nitrogen to freeze soft samples such as animal tissues or plastics until they become brittle before grinding can be carried out.